Bupropion (Wellbutrin) For Sexual Dysfunction: The Hard Science

Bupropion (Wellbutrin) For Sexual Dysfunction

If you have been exploring treatment options for sexual dysfunction, you might have come across Wellbutrin as a potential solution. This article reviews some of the current evidence available.

Sexual dysfunction can significantly impact a person's quality of life, affecting aspects such as desire, arousal, and satisfaction. For individuals experiencing sexual dysfunction, finding effective treatments is crucial to restoring a healthy and fulfilling sexual life. Alternatively, switching to an antidepressant with a low risk of sexual side effects may be an option.

Wellbutrin, also known by its generic name Bupropion, belongs to the class of antidepressants but operates differently from the commonly used SSRIs. While SSRIs are known for their potential to cause sexual dysfunction, some studies suggest that Wellbutrin might offer a different outcome.

Evidence and Studies

• Research has explored the role of Wellbutrin in managing sexual dysfunction. However, Wellbutrin is not FDA-approved for use in any sexual dysfunction disorders.
  
  
• Several studies have compared Wellbutrin to other antidepressants, particularly SSRIs, known for their impact on sexual functioning. 
  
  
• A systematic review and meta-analysis (Patel et al., 2016) found that Wellbutrin did not significantly differ from placebo in causing sexual dysfunction. It appeared to improve sexual functioning in individuals who experienced sexual dysfunction due to SSRIs.
  
  
• Another systematic review (Razali et al., 2022) aimed to assess the efficacy of bupropion in treating female sexual dysfunction. The study revealed that bupropion exhibited a nearly three-fold improvement in addressing issues related to sexual desire, with lower dosages (150 mg vs. 300 mg) demonstrating more significant enhancements in women with hypoactive sexual desire disorder (HSDD).
  
  
• Consequently, the article suggests a promising potential for Bupropion as an effective treatment option for women experiencing HSDD.

Treatment Considerations

• When considering Wellbutrin for addressing sexual dysfunction, it's important to work closely with a healthcare specialist, as there are currently no official recommendations for its use as an off-label treatment for this indication.
  
  
• Taking Wellbutrin for sexual dysfunction should primarily be considered as an alternative in depressed patients suffering from side effects due to their current antidepressant.
  
  
• Typically, Wellbutrin is prescribed in doses ranging from 150 mg to 450 mg per day when used in its extended-release format for the FDA-approved indication (i.e. depression).

Contraindications

• Seizure disorders or history of seizures.
  
  
• Abrupt discontinuation of alcohol or sedatives.
  
  
• Active eating disorders (anorexia nervosa, bulimia nervosa).
  
  
• Concurrent use or recent discontinuation of Monoamine Oxidase Inhibitors (MAOIs) within 14 days.
  
  
• Allergy or hypersensitivity to Bupropion or its components.

Side Effects From Wellbutrin

• The side effects of taking Wellbutrin for sexual dysfunctions may include headaches, dry mouth, sore throat, insomnia, dizziness, constipation, and increased pulse. These side effects typically subside within the first few months of treatment.
  
  
• Bupropion is well-tolerated by most individuals. It has a low risk of sexual dysfunction and absence of weight gain commonly associated with SSRIs.
  
  
• Bupropion increases the risk of seizures, particularly in those with a predisposition to epilepsy. Bupropion is also contraindicated for any other factors predisposing to seizures, such as discontinuation of alcohol or sedatives, brain tumors, and head trauma.
  
  
• The FDA has issued a black box warning for Bupropion because of the potential increased risk of suicidal thoughts and behaviors in depressed children, adolescents, and young adults. 

Author: J. Martin, M.D. 
Last updated: August 26, 2023

Disclaimer: Disclaimer: The information provided is intended for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider, such as a physician, before starting any new treatment or making changes to your existing treatment plan. Individual responses to treatment may vary, and a healthcare professional can provide personalized guidance based on your specific needs and circumstances. If you are experiencing severe or persistent symptoms of disease seek immediate medical attention.