Using Sertraline (Zoloft) For Premature Ejaculation

Sertraline may provide off-label help for those struggling with premature ejaculation. Photo by Ron Lach at Pexels.com

Sertraline For Premature Ejaculation

Below you will find a practical summary of current evidence and information about taking Sertraline for premature ejaculation.

Premature ejaculation is a common sexual health problem where males experience frequent and reoccurring loss of control of the male orgasm in very early stages of sexual contact.

Sertraline is classified as a selective serotonin reuptake inhibitors. It works through preventing the reuptake of serotonin in the brain's nerve endings, therefore increasing serotonin's effect on the brain. Sertraline is most commonly known under the brand name 'Zoloft'.

Provided information is not individual medical advice. Always consult with a physician or psychiatrist before starting Sertraline for premature ejaculation.

Evidence

• Using Sertraline for premature ejaculation is considered off-label, which means it does not have an approval from the FDA due to the lack of large clinical trials support its efficiency.

• A systematic review from 2019 found that Sertraline prolonged intravaginal ejaculation latency time in those suffering from premature ejaculation, while also improving the sexual satisfaction rates of the patients and their respective partners.

Treatment with Sertraline For Premature Ejaculation

• The off-label dosage of Sertraline for premature ejaculation is commonly between 25-100 mg daily. 

• A research study from 2021 indicates that taking Sertraline for premature ejaculation "on-demand" may be equally effective to taking it regularly, while leading to less side effects. In this study, the "on-demand" group took 50 mg of Sertraline 4 hours before sexual intercourse.

Side Effects of Sertraline (Zoloft)

• Some common side effects of taking Sertraline for premature ejaculation include dizziness, nausea, loss of appetite, dry mouth, diarrhea, difficulty sleeping, and increased sweating.
  
  
• While prolonging orgasm might be a desired effect from Sertraline, its usage may cause non-desired side effects including decreased libido (sexual desire) and erectile dysfunction.
  
  
• Rare side effects of Sertraline include severe weight loss, increased risk of bleeding (particularly when taken with other blood-thinning medications), seizures, and serious allergic reactions.
  
  
• The FDA has issued a black box warning for Sertraline because of the increased risk of suicidal thoughts and behaviors in children, adolescents and young adults.
  
  
• It is important to speak with your healthcare provider if you experience any of these side effects while taking Sertraline.

Absolute Contraindications

• Taking or having taken an MAOI drug in the last 14 days.

• Known allergy to Sertraline or any other selective serotonin reuptake inhibitor.

• Moderate to severe liver problems.

Useful Information

• There is was no comparative difference in between taking Citalopram (another SSRI) or Sertraline for premature ejaculation. Another commonly used medication for premature ejaculation is Paroxetine. 

Author: J. Martin, M.D. 
Last updated: August 31, 2023

Disclaimer: The information provided is intended for general informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider, such as a physician, before starting any new treatment or making changes to your existing treatment plan. Individual responses to treatment may vary, and a healthcare professional can provide personalized guidance based on your specific needs and circumstances. If you are experiencing severe or persistent symptoms of disease seek immediate medical attention.